In theory, font and DPI scaling in Winforms are automatic. In practice... not so much.
I've noticed that it copes better with vertical scaling than horizontal, but even then it's far from perfect.
In my experience, scaling is only reliable when you do one of two things:
Don't use the designer at all. This is quite painful, but it does give you the requisite amount of control over your layout.
Use the built-in layout controls - specifically, the
TableLayoutPanel. These guys are your best friends; I rarely do anything in Winforms without them anymore.
In your case, I'd probably go with #2. Based on the screen capture, I think it would be quite easy to fit your layout into a combination of
FlowLayoutPanel containers - possibly even just one
You should look into the AutoScaleMode and AutoSize features. Combined with the docking abilities you should be able to achieve what you want.
I had a really good article on that but the link is dead... anyway, this should get you started:
This may not solve your problem.
But we learnt the hard way that Label and the text controls should be stacked vertically, i.e. place the Text Box below the Label, instead of next to the label. This solved a lot of problems for us including support for multiple languages as text width in different languages can be more than English text